Aniline cancer

by I. Berenblum

Publisher: John Wright in Bristol

Written in English
Published: Pages: 355 Downloads: 334
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  • Cancer.

Edition Notes

Statementby I. Berenblum.
The Physical Object
Paginationp.337-355 ;
Number of Pages355
ID Numbers
Open LibraryOL18769044M

Information regarding the occurrence of cancer of the bladder attributed to aniline is gathered together. While the accuracy of the data in relation to occupational exposure is imperfect, the case is sufficiently made out to establish the existence of cause and effect between exposure to aniline compounds and bladder cancer. But the carcinogenic influence is much slighter than for pitch. Applications focused on large (>1kD) biologic or immunologic agents for cancer drug discovery or development may be assigned to OTC (12). Applications developing small molecule drugs that can enter cells easily due to a low molecular weight (cancer drug development and therapy may.   Abstract. Aim To investigate bladder cancer risks in workers from a factory manufacturing chemicals for the rubber industry.. Methods The mortality (–) and cancer morbidity experience (–) of a cohort of male production workers from a chemical factory in north Wales were investigated. Exposure estimates (or surrogates) were developed for four chemicals: 2 Cited by: - AFBPFSWMIHJQDM-UHFFFAOYSA-N - N-Methylaniline - Similar structures search, synonyms, formulas, resource links, and other chemical information.

Chemical structure of aniline. Aniline was first isolated from the destructive distillation of indigo, a plant used to produce blue dye, in In , it was also isolated from coal tar. Further attempts by several scientists yielded aniline by different processes and, in , C. J. Fritzsche gave this blue oil the name “aniline,” from the specific name of one of the indigo-yielding. Aniline A chemical compound implicated, along with o-toluidine, in the causation of bladder cancer. Aniline and o-toluidine, both aromatic amines, are used in the manufacture of a variety of dyes, pharmaceuticals, pesticides, and chemicals employed in the manufacture of rubber. Aniline, an organic base used to make dyes, drugs, explosives, plastics, and photographic and rubber chemicals.. Aniline was first obtained in by the destructive distillation of name is taken from the specific name of the indigo-yielding plant Indigofera anil (Indigofera suffruticosa); its chemical formula is C 6 H 5 NH Aniline is prepared commercially by the catalytic. Cancer Books here CANCER SITES: Prostate cancer survivor Larry Clapp addresses cancer causes and effective alternative treatments for reversing prostate cancer without drugs or surgery, so cancer .

Our water-soluble aniline water stains are made from aniline dyes. Unlike pigmented stains, these do not mask the natural grain and texture of the wood. They are inexpensive and easy to blend. They penetrate well and can be used under any type of finish. The stains can be applied by dipping, sponging, brushing, or spraying. These are concentrated. Bladder cancer is an uncontrolled abnormal growth and multiplication of cells in the urinary bladder, which have broken free from the normal mechanisms that keep uncontrolled cell growth in check. Invasive bladder cancer (like cancers of other organs) has the ability to spread (metastasize) to other body parts, including the lungs, bones, and. Get this from a library! Bioassay of aniline hydrochloride for possible carcinogenicity.. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.].   When news of the cancer cluster leaked in , there was the predictable townwide panic, including a run on bottled water supplies. aniline. That .

Aniline cancer by I. Berenblum Download PDF EPUB FB2

In the most methodologically vigorous study, one death from bladder cancer was reported among men who had produced or used aniline, with deaths expected from population rates1. A recent mortality study of men employed in the manufacture of organic dyes, in which two of the three processes involved aniline as a raw material, showed no death from bladder cancer2.

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Aniline dye cancer was discovered in Germany in the s, largely because Germany by this time was the world's leading producer of synthetic colorings. German professional societies were the first to establish informal standards for radiation protection, not just because X-rays.

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Described as Aniline cancer book guide book for those diagnosed with cancer, Life Over Cancer provides patients with the benefit of his knowledge and experience in treating cancer for thirty years.

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Confronting what medicine knows about the illness and the little-known workings of his body's natural cancer ­fighting capacities, and marshaling his own will to live, Servan-Schreiber found. The U.S. EPA IRIS program has determined that aniline is a probable human carcinogen based on sufficient evidence in laboratory animals and inadequate evidence in humans.

The potential for aniline to cause cancer in humans has not been assessed by the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC). There is alot of information online that you could access easily. Just search aniline and cancer. The EPA site, PubMed, and NCBI sites are a good start.

Most of my references Aniline cancer book my new book are from Toxicology textbooks and reference books. People can always use Septocaine instead and avoid the ingredient completely. Aniline acts through an intermediate to change hemoglobin to methemoglobin. In one subject, 65 mg of aniline increased the methemoglobin level by 16% within 2 hours.

Intense methemoglobinemia may lead to asphyxia severe enough to injure the cells of the central nervous system. Aniline causes sarcomas predominantly in the spleen, nitrobenzene produces liver adenoma and carcinoma in the rat.

Both agents acutely produce methaemoglobin and chronic anaemia, and liver and kidney damage in rat and mouse. The Death of Cancer,by ,Jr.

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From all your friends here at we send "Hope, Courage and Strength". aniline-induced carcinogenicity in mice of either sex (National Cancer Institute, ~. This carcinogenesis bioassay was conducted according to the usual National Cancer Institute (NCI) protocol, which utilizes an MTD and one-half MOD as the doses for the study.

Cancer is the second leading cause of death in the United States. Lung cancer is the leading cause of cancer death in adults; leukemia is the most common cancer in children.

Other common types of cancer include breast cancer (in women), prostate cancer (in men), and colon cancer (see also Hodgkin's disease). The incidence of particular cancers varies around the world and sometimes according to. Lung cancer is the leading cause of cancer death in the United States in both men and women.

Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell. By far the most common source of these insults is tobacco smoke, which is responsible for about 85% of U.S.

lung cancer deaths (see smoking). Learn about benzidine, exposure to which raises your risk of bladder cancer. Benzidine is a manufactured chemical. In the past, benzidine was used to produce dyes or products used in clinical laboratories. However, benzidine has not been sold in the United States since the mids.

I have had an email from Debby Hallett at BASF asking me to pass the following information re Urine Test. They have a dedicated team at BASF Occupational Health and this is the direct email you need to get on the list: [email protected] she did say 4 of you have already made contact and she has passed your info over, everyone else should email direct.

ACGIH ® is a (c)(3) charitable scientific organization that advances occupational and environmental health. For over 80 years, we've been respected for our dedication to the OEHS community.

For over 80 years, we've been respected for our dedication to the OEHS community. An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity.

Check for active clinical trials using this agent. Benzene is a colorless, flammable liquid with a sweet odor. It evaporates quickly when exposed to air. Benzene is formed from natural processes, such as volcanoes and forest fires, but most exposure to benzene results from human activities.

Benzene is among the. Cancer is a uniquely western problem. One out of three Americans die of cancer, it used to be one out of four. People in China, Japan and Southeast Asia seldom have cancer.

Yet in North America, Australia, New Zealand and affluent countries in Europe cancer is epidemic. “Clayton Aniline was found guilty of negligence in a similar matter more than 10 years ago yet others who developed bladder cancer after exposure to Author: Beth Abbit.

P.K. Gupta, in Biomarkers in Toxicology, Substituted anilines. Substituted aniline, an alachlor herbicide, was registered and introduced in for the pre-plant or pre-emergent control of a broad spectrum of grass, sedge, and broad leaf weeds (Heydens et al., ).The commonly used herbicides are alachlor, acetochlor, butachlor, metolachlor, and propachlor.

Summary: Aniline is a clear to slightly yellow liquid with a characteristic odor. It does not readily evaporate at room temperature. Aniline is slightly soluble in water and mixes readily with most organic solvents. Aniline is used to make a wide variety of products such as polyurethane foam, agricultural chemicals.

The manufacture of magenta was classified as entailing exposures that are carcinogenic. Of the four aromatic amines, 4,4'-methylene bis(2-chloroaniline) (MOCA) was classified as probably carcinogenic to humans.

para-Chloroaniline and 2,6-dimethylaniline were classified as possibly carcinogenic; N,N-dimethyl-aniline could not be classified. Although there was an increase in bladder cancer in workers exposed to "aniline and o-toluidine" in one study, the authors concluded that o-toluidine was more likely the responsible agent (Ward et al., ).

Due to the concomitant exposure of examined populations to other chemical substances, and the lack of analyses of outcome with duration.

However, an example of MARS to recover a more valuable chemical is given in the Case Study contained in Table commercial value of fluoroaniline is ten times the aniline value (around $ kg ­1).In the example given the treatment of 10 m 3 d ­l wastewater with a 5 g L ­1 fluoroaniline concentration is considered.

The MARS process in this case is able to deliver a net benefit through. Hydroxylamine compounds (e.g., aniline metabolites phenylhydroxylamine and aminophenol) often produce methemoglobin that is refractory to conversion back to normal hemoglobin by administration of methylene blue, and can precipitate acute hemolytic anemia (1–4).

Paradoxically, methylene blue can be a source of oxidant stress and, in high doses. 2-Methylnitroaniline is one of the laser-induced decomposition product of Pigment Red 22 and Pigment Red 9 (widely used azo compound).

The electron charge distribution of 2-methylnitroaniline has been investigated from high-resolution single crystal X-ray data and ab initio calculations.Is an aromatic amine.

It is a colorless, oily liquid, originally obtained from indigo, a blue dyestuff derived from several plants, by distillation.

Today it is largely manufactured from coal tar or.2-Chlorobenzenamine. Molecular Weight: O-chloroaniline is a clear amber liquid with an amine odor. Occurs in both alpha and beta forms.

(NTP, ) from CAMEO Chemicals. Expand this section. 2 Names and Identifiers. Expand this section. 3 Chemical and Physical Properties.

Expand this section. 4 Spectral Information. Expand this section.